Natural chemical drug production research institute

Production and research company of antioxidant product
(antioxidant dressing, macular degeneration treatment, cardiovascular treatment)

New Testament : Cardiovascular treatment

'9-cis β-carotene' is absorbed into the body and degrades into '9-cis retinoid' which destroys blood fat cells and 'all trans retinoid' which acts on thrombus and neutralizes blood coagulation. Both substances have efficacy in Atherosclerosis therapy.

Research Field(Raw material) : New Testament candidate discovery

01
Strain collection

Marine microalgae and marine bacteria collection

02
Strain development

Optimal culture and mass production technology

03
Culture

Optimal culture by utilizing the optical bio-reactor

04
Separation

  • Supercritical refinery
  • Carotenoid refinement system(Aerogel+Hydroxyapatite Ion exchange technology)
  • Isomeric refinement system

05
Refinement

Crystallization Technology

Research Field(Raw material) : New Testament candidate discovery

01
Screening

Micro-Western Blot Test

Research Field(Raw material) : New Testament candidate discovery

01
Molecular Modeling

Formulation Research ; Liposome (Oral administration), Micelle (injection)

02
AMDE

Experimental treatment of the '9-cis β-carotene' to the organ in vitro

Research Field(In vivo) : Experiments on drug efficacy and toxicity

01
PK(Pharmacokinetic part)

9-cis β-carotene extract from Duniliella Salina : Rapid pharmacokinetics and toxicity testing of single-vein and oral administration using a rat (Sprague-Dawley)

02
PD(Pharmacodynamic part)

Underway in 2018

03
TK(GLP)

Schedule to be in 2019

Research Field(PBPK) : The discovery of a new drug candidate

01
On-chip Test

Testing models that imitate more than 98 % of actual human organs provides a more accurate understanding of the causes of changes in drug metabolism and the incidence of disease.

Artificial On-Chip Size

  • Housing: 100mm x 35mm x 50mm
  • Vascular channel: 100µm
  • Media channel: 40µm
02
On-chip System