Natural chemical drug production research institute

Production and research company of antioxidant product
(antioxidant dressing, macular degeneration treatment, cardiovascular treatment)

New Drug: Cardiovascular Drugs

9-cis β-Carotene is discomposed into two substances, 9-cis Retinoid which break down fat cells in the blood and All-Trans-Retinoid that neutralize blood clotting by acting on the thrombus. Both of them have efficacy in the treatment of atherosclerosis.

Research Field(Raw Materials): New Drug Candidate Discovery

01
Culture Collection

Marine microalgae and marine bacteria collection

02
Strain development

Optimal culture and mass production technology

03
Culture

Optimal culture by utilizing the optical bio-reactor

04
Isolation

  • Supercritical Purification Device
  • Carotenoid purification system(Aerogel + Hydroxyapatite Ion exchange technology)
  • Isomeric purification system

05
Purification

Crystallization Technology

Research Field(Screening): New Drug Candidate Discovery

01
Screening

Micro-Western Blot Test

Research Field(In Vitro): ADME(Absorption, Distribution, Metabolism and Excretion)

01
Molecular Modeling

Formulation Research ; Liposome (Oral administration), Micelle (injection)

02
ADME

Test for the ADME of ‘9-cis β-carotene’

Research Field(In vivo) : Verification of Drug Efficacy and Toxicity

01
PK(Pharmacokinetics)

9-cis β-carotene extract from Dunaliella Salina: Rapid PK and toxicity tests of single dose intravenous and oral administration using a rat (Sprague-Dawley)

02
PD(Pharmacodynamics)

In progress 2018

03
TK(GLP)

Scheduled in 2019

Research Field(PBPK) : Physiologically based pharmacokinetic model

01
On-chip Test

Testing models that imitate more than 98% of actual human organs, it could be more accurate discovering the changes of PBPK and the causes of diseases.

Artificial On-Chip Size

  • Housing: 100mm x 35mm x 50mm
  • Vascular channel: 100µm
  • Media channel: 40µm
02
On-chip System